Dave has answered all your main questions.
Using this method it is not a very big task to undertake.
Just do the preparation re car sleeping and then measure the voltage readings for each fuse.
Make sure you do it systematically ie draw a diagram or print out the fuse location diagrams (
https://w220.ee/Fuses) and record the voltage drop across each fuse.
Then add them to a table/chart and upload here and we can help analyse the results.
BTW my update W220 must have a bonnet/hood switch because the other day I drove off the bonnet unlatched and the dashboard lit up red warning me. I don't where it is located though and it is certainly not obvious.
Brian
Mine is a pre facelift, and did exactly the same red message one day, when I moved it a few feet in my drive with hood up :wink
That's how I know it must have switch(es), like Brian says, they aren't obvious, I've never needed to look for them :wink
I assumed they are in the left and right hood locks, like on other vehicles.
So, now, on all Mercedes I snap them closed with the bonnet up when testing for Current Draw :wink
Remember to snap shut Right Rear Door lock too :wink
And
Remember to unlatch them before slamming Hood / Door shut or you will likely damage something, I always tie a bit of
red cloth / ribbon / tape around the Door Handle and Front Grille to remind me :laugh
Yes ATA =
Anti
Theft
Alarm, and yes switch on dashboard, turn it off as per owners manual, so that the motion sensors inside the car do not detect your movements :wink
I cannot answer your question about 0.6 V drop overnight, I've never bothered measuring that:wink
IMHO that test is not worth doing as it depends on a variety of things like Battery age / condition, and how long is the "night" :wink
If I have a car with a drain, I simply get to and start pulling fuses, like I said, I always start at the Rear Box under Seat, as most of the cars I've had draining Battery have had Water Ingress damage to Modules or Wiring Plugs in the rear end of the car, which has caused the drain :wink
:laugh A Jaguar I did recently had a "Swimming Pool" under the Rear Seat Squab, and one of the Heated Seat power feed plugs was actually emitting steam as it was drawing current :laugh
Cause was a leaking bonded rear screen !!
Couldn't visibly see that until I lifted the Rear Seat Squab to get at the Fuses :grin
HTH
Cheers Dave