Apologies for this long Post but it might be of help to others here with similar issues.
Some of you kind & helpful Folks might remember my recent Nightmare of 3 x ‘flat’ battery issues within a month, 3 x roadside rescue & jump starts, 2 x replacement new batteries 'dying' overnight, being effectively Grounded for 2 weeks during the Christmas & New Year hols etc. A truly frustrating experience after 6 years of reliable & trouble-free ownership of my otherwise immaculate 18 year-old W220.
Today: my local ‘wizard’ auto electrician spent a couple of hours THOROUGHLY investigating the root cause of the problem. After testing Current Draw (Milliamps) from the various complex electrical systems on my W220 when ‘Asleep’ (by ‘Asleep’ I mean the car, not him
), he narrowed the problem down to a faulty / ‘stuck’ manual boot (trunk) release button - which also has an electrical connection to the PSE system for the soft-close / locking feature. His Verdict? Maybe water ingress in the release button and / or due to its age. But, either way, it was keeping the PSE system ‘awake’ and draining the battery constantly 24/7 even with the ignition switched off and the car locked. 
So… he disconnected the power supply from the ‘manual’ release button to the PSE system (after removing the boot-lid lining it took only 10 seconds) and HEY PRESTO!: Current Draw when the car is ‘asleep’ was about 50 milliamps - as it should be. With the boot release button re-connected temporarily: Current Draw was massively higher (about 3 Amps as I remember): which explained the almost overnight battery drain issue despite 3 perfectly healthy batteries.
Result: the car is mobile & reliable again - Hoorah!🕺 No anticipated further battery drain issues, the PSE works fine to auto lock / unlock the doors & boot etc remotely via the key fob.
So no further action needed unless for some reason I need / choose to replace the faulty ‘manual’ boot release button? I can live with that since the detachable blade key will still work if ever needed. 🤞
My Conclusion / Lesson(s) Learned?
1. I had mistakenly..🙄.. attributed the very first (OE spec) battery failure to it being 6 years-old and having ‘expired’ at the beginning of the recent Cold Snap here in the UK. BUT.. with hindsight it was almost certainly ‘False Logic’ on my part when the original battery was probably still perfectly healthy. (I like to think I know enough about car batteries to be careful with maintaining their health, i.e never run heavy drain electrical Auxiliaries - lights, wipers etc unless the engine is running).
2. Instead of ‘Jumping’ (ha ha) to the WRONG Conclusions and buying my way out-of the situation with TWO new batteries I SHOULD have had the Current Draw investigated FIRST. And.. it would have saved me a massive amount of Time, Hassle & Costs over the last month or so. $$$ £££ etc. Hey ho....
3. (As in my case..) if you don’t have the technical expertise & experience to thoroughly investigate & diagnose the root cause of a problem with your prized Mercedes (or your Dishwasher / Central Heating Boiler etc etc?), engage a Trusted / Recommended Expert to do it for you. It can often save Time, Money & Hassle in the long run.
To quote an old Saying: ‘A little Knowledge can be a Dangerous Thing’. Enough said?
Best wishes & thanks for your kind help & support on this excellent MB Forum. To be Continued…
MB
‘The Best or Nothing’
Some of you kind & helpful Folks might remember my recent Nightmare of 3 x ‘flat’ battery issues within a month, 3 x roadside rescue & jump starts, 2 x replacement new batteries 'dying' overnight, being effectively Grounded for 2 weeks during the Christmas & New Year hols etc. A truly frustrating experience after 6 years of reliable & trouble-free ownership of my otherwise immaculate 18 year-old W220.
Today: my local ‘wizard’ auto electrician spent a couple of hours THOROUGHLY investigating the root cause of the problem. After testing Current Draw (Milliamps) from the various complex electrical systems on my W220 when ‘Asleep’ (by ‘Asleep’ I mean the car, not him
So… he disconnected the power supply from the ‘manual’ release button to the PSE system (after removing the boot-lid lining it took only 10 seconds) and HEY PRESTO!: Current Draw when the car is ‘asleep’ was about 50 milliamps - as it should be. With the boot release button re-connected temporarily: Current Draw was massively higher (about 3 Amps as I remember): which explained the almost overnight battery drain issue despite 3 perfectly healthy batteries.
Result: the car is mobile & reliable again - Hoorah!🕺 No anticipated further battery drain issues, the PSE works fine to auto lock / unlock the doors & boot etc remotely via the key fob.
So no further action needed unless for some reason I need / choose to replace the faulty ‘manual’ boot release button? I can live with that since the detachable blade key will still work if ever needed. 🤞
My Conclusion / Lesson(s) Learned?
1. I had mistakenly..🙄.. attributed the very first (OE spec) battery failure to it being 6 years-old and having ‘expired’ at the beginning of the recent Cold Snap here in the UK. BUT.. with hindsight it was almost certainly ‘False Logic’ on my part when the original battery was probably still perfectly healthy. (I like to think I know enough about car batteries to be careful with maintaining their health, i.e never run heavy drain electrical Auxiliaries - lights, wipers etc unless the engine is running).
2. Instead of ‘Jumping’ (ha ha) to the WRONG Conclusions and buying my way out-of the situation with TWO new batteries I SHOULD have had the Current Draw investigated FIRST. And.. it would have saved me a massive amount of Time, Hassle & Costs over the last month or so. $$$ £££ etc. Hey ho....
3. (As in my case..) if you don’t have the technical expertise & experience to thoroughly investigate & diagnose the root cause of a problem with your prized Mercedes (or your Dishwasher / Central Heating Boiler etc etc?), engage a Trusted / Recommended Expert to do it for you. It can often save Time, Money & Hassle in the long run.
To quote an old Saying: ‘A little Knowledge can be a Dangerous Thing’. Enough said?
Best wishes & thanks for your kind help & support on this excellent MB Forum. To be Continued…
MB
‘The Best or Nothing’