Blue locktite (or however it's spelt) = breakable with a wrench
Red locktite = may need heat or a lot more grief.
Both are, IMHO more blind faith or luck rather than judgement as things like grease or corrosion on the threads can stop a proper bond.
Shake-proof washers, hmmm....
Locknuts (one nut tightened down on top another) okay, but obviously can't be used on blind bolt holes (i.e. where the bolts don't go through and out the other side).
Nylocs are fine for general use. Again can't be used on blind holes.
Flange bolts (like a regular bolt with a larger base to the head, kind of like a washer, and serrated on the underside) are okay, but not great. Flange nuts likewise.
Aerotight nuts (see picture) better, but can only be used once as the splits in the top of the nut are supposed to deform when tightened. Again can't be used on blind holes.
Castellated nuts with a split pin: superb. Most motorcycles used to (still do?) use them on their wheels.
Best of all: lockwire.
If you look at racers they lockwire just about everything, as do vintage planes and most helicopters. But it's probably overkill for most car applications.
True story about shake-proof washers:
Back in the 80s I used to pull pints in a pub in England. The landlady, Sue, once worked at the old Triumph motorcycle factory. Her job was to put the tail-light clusters onto the back mudguards of the old Bonnevilles. She had a line of Bonnevilles, a rack of light clusters, a bin full of bolts, a bin full of nuts, and a bin full of shake-proof washers.
Now Sue had never seen a shake-proof washer before. She knew what a regular washer looked like, but not a shake-proof one.
So she figured they were all broken. And didn't use them.
So, for about six weeks every Bonneville came out of the factory without shake-proof washers holding on the tail-light clusters, and, of course, if the problem wasn't caught, they all fell off.
Luckily for motorcyclists everywhere, Sue soon married 'Enry and began her career in the licensed trade.