Well, if the amplifier (or anything else on the circuit) is pulling too many amps the fuse will blow. Make sure all the items on the circuit are pulling less that the rated amperage and that there is no short.
Figgerd it out, aside from the fact that I just installed a 4x52wt deck and failed to find the amplifiers in time, well lets put it this way. I think you said it best in your sig.
" Artificial intellegance is no match for natural stupidity." 
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