Nope, will not work in the ML. The 2004 ML should be a DVD.
the 2006.1 refers to the map version, not the DVD drive itself. navteg issues updates regularly. get your fact straight before you post.You need a dvd for a 2003-2005 model. the 2006 dvd will not work. The one that you listed above will not work either because it's in the cd format. The older ml's (2000-2002) had a cd based nav. The newer ones (2003-2005) have a dvd based nav. I have had quite a bit of expirience with this. It took me forever to track a dvd down for a 2005 at a decent price.
I really don't think you understand how this all works so I will try to explain it to you. You can have a 2006.1 or a 2006.2 or even a 2010.2 and will work fine in the w163 as long as that's the vehicle it's made for. I'm not saying that yours doesn't work. What I am trying to explain to the op is that the disc for a 2006 year model ml will not work because it is a w164, neither will a cd nav disc because that is for a 2000-2002 year model which has a cd-based system and not the DVD based system like the 2003-2005 has. I really don't know how much plainer I can make it for you. It sounds like you have a hard time understanding english. Please don't be insulting just because you don't understand.that's funny, I have the 2006.1 DVD and working fine in the DVD navigation drive in the W163. I can put in a 2006.2 or newer map in the DVD drive and it will continue to work as long as the map is specific to the MCS system. Now who is not getting the fact straight.