Dan is right. The combination of the w140 at 4500lbs and the stock Michelin MVX's propensity to 'flat-spotting' conspire for some serious shakin'! It's especially severe in my case, since I only drive my S420 about once a week. The first five miles can be almost punishing, to where I can see riples in my coffee cup, and it's especially bad between 35-65mph. I too made numerous trips to various shops to have the tires balanced. If your vibration is constant, regardless of how long you've been driving the car, then your ball joint may be the culprit.