I had the same problem, the Smart key opened the windows and roof from the passenger side only, but not the driver's side. More than likely, it is the IR sensor located in the lock cylinder. The lock cylinder is about $130.00 and installation approximately an hour. To get a replacement lock cylinder, you will probably have to get it from the MB dealer because MB cracked down back in November on security and the documentation to get a replacement.
Also, try replacing the batteries in the remotes as they tend to get lazy as the batteries get weaker.
Also, try replacing the batteries in the remotes as they tend to get lazy as the batteries get weaker.