Patrick,
Inspect your front and rear flex disks for hairline cracks as the the hill climb of the Grapevine on HWY 5 may exacerbate any flaw by a chronic vibration because of the long steep climb. Also, if you take HWY58 through Barstow may cause the problem too, inspect those with a magnifier and a flash light.
Next, I would inspect the drivers transmission lead-out hose. The line is steel out of the transmission, but from the front of the engine to the back of the radiator is a rubber hose with a coiled spring, so it does not kink over the entire one-foot hose. I believe you can pull back the spring over the hose, and feel how hard it is, yet you may not pull back the on some hoses, but you can test the hardness with a screw driver. If it is hard replace that sucker like ASAP. The return line will be always softer as that line will always have cooler fluid due to the transmission fluid already passed through the radiator cooler.
You break that exit rubber line on the highway, and in a matter of few minutes you will destroy that tranny..
On these old distributor cars, this is me. I would always carry a cheapy dremil motor tool along with a cheap 12v to 120v inverter. Carry a small file set along with some 220 grit sandpaper. Do not forget the screw driver to take the distributor cap, and the hex wrench or socket hex bit with a extension and ratchet to get the rotor off to clean it. The weather now is cold/wet/misty and snowy now. With the dremil tool use a worn sanding drum, so it is not so abrasive, and you can wear-out the drum on a rock or on the highway road.
https://www.harborfreight.com/rotary-tool-kit-80-pc-63235.html
Take your pick from a $19 to $40 inverters. I have one of the $40 dollar units
https://www.harborfreight.com/catal...,f,EAFeatured+Weight,f,Sale+Rank,f&q=inverter
Forgo the inverter and the cheap corded motor tool, and get a cordless tool. Just remember to charge it before your trip...
https://www.harborfreight.com/96-volt-cordless-variable-speed-rotary-tool-kit-63234.html
I'd carry about two long spark plug wires if you develop a mis-fire you can change the wires on the fly. Get some from the junk yard.
Along with the wires, get a cheapy volt/ohm meter, so you can test the ohms of ignition wires encase of a misfire, or test the battery voltage at the battery to see if you get a alternator failure as a battery charging will be in the 13v - 14v or so at the battery with the engine running.
https://www.harborfreight.com/7-function-digital-multimeter-63604.html
I always travel with air gauge and a compressor in every car... I have one of these:
https://www.harborfreight.com/12v-100-psi-high-volume-air-compressor-69284.html
I always carry patches too for nail and screw punctures(I carry solutions to fix my problems instead of being stuck in some town)....
https://www.harborfreight.com/tubeless-tire-repair-kit-9-pc-62611.html
Carry gloves, and extra fuses. If you blow the front cigarette lighter fuse on these distributor W140's is tied to the security module of the car that it will not permit you to start the car. Been there done that... Inflate your tires with your new air pump with the rear door cigarette jacks.
If you ever experience a no start on these cars, always check your fuses first. Your car has two ignition coils, and each has a fuse of 10Amp or 7.5amp, so have those fuses. I carry a sandwich zip-lock bag full of fuses from the junk yard cars from the times I have gone to the junk yards.
Carry tools, carry an adjustable wrench to remove the front hex cap on front of the fuel rail to test if the system is pressurized by pressing the shrader-valve to see if the fuel squirts out with force...
I would carry a four wire temperature at the front top of the intake as you loose that sensor and your M119 will not start. Get a new one or one from a junk car... That sensor can be changed once the car has cooled, or you will have to drain the radiator to relive the pressure to replace it hot.
Next, either carry the diluted coolant you use, or just carry a gallon or two of distilled water from the grocery store. Put the gallon in a bucket, or carry it in the new plastic grocery bags we buy in Kalifornia as those one gallon jugs are prone to leakage real easy on the road.
Always have a flashlight near you. Understand, that the weather is real cold around the base of the Grapevine grade right now, and yesterday the Highway Patrol was escorting waves of cars due ice and snow, so understand they can close it then you will be asked to detour toward Barstow(Hwy58) or Santa Maria (Hwy166 to Hwy 101). Been there done that, and it added 6hrs to the trip through Santa Maria. Carry a blanket. Carry snacks that can replace a meal, and water to drink... I'd say carry chains, but is a risk you need to take. They may not let you through if you do not carry chains. For chains most do not know how to install them, so that is risk too.. Been there done that too... They let me through because they saw I had chains once, so your call...
Lastly, That straight bypass hose from the thermostat top housing to the intake manifold make sure it is not all white with a small crust where the hose touches metal. Replace the hose, but one needs to scrape all that corrosion on the neck of where the hose attaches to the metal. Go over the hose clamps too.
Ahh one last thing, I carry a infrared laser thermometer, so I can point it at the thermostat housing encase you loose that temperature gauge on the road as loosing this gauge on the road can make you a nervous-wreck, but pointing the laser to the thermostat housing and reading 85C to 90C can qualify everything is working okay if the car starts to get hot turn on the heaters to high with the fans to high too. That can cool around 5 degrees....
I carry one of these:
https://www.harborfreight.com/non-contact-pocket-thermometer-93983.html
With the 722.3 tranny at 65 to 70mph you will average 22mpg along with that. I would become a Costco Warehouse member as the fuel is over priced all over the highways. Fillup in your area. It will take 1/2 to 2/3rds tank to make it to Costco in Bakersfield of Hwy99 of Rosedale exit of Costco is to the right off the freeway.The gas station takes only ATM no credit. They close at 9:30M-F, 8pm on Sat, and 7:30PM on Sun...Stop to eat and go to the restroom as the the Costco restrooms are super clean. I look up all the Costco's on all my trips. Can save about $10 bucks per fill ups, so sign up to costco and plan your trip according and time the Costco closing times too...
https://www.costco.com/warehouse-locations/bakersfield-ca-688.html
I have been doing these trips for 30 years, and you can get to costco from Hwy 5 by taking the HWY46(Wasco/Lost hills) it will get you to Hwy99 from Hwy 5. Hwy 46 is past Kettleman City.
https://www.google.com/maps/search/is+hwy+5+open+at+the+grapevine/@35.8185233,-119.8258789,10z
Sounds like a lot, but this is how I travel.....
Martin