Today my E300 stopped changing gear today, I can select reverse and go backwards, and neutral works ok, and drive goes forward, but once in drive or 4,3,2 or 1 it stays in the same gear (second I think) and wont change up or down.
first things first, check your fluid level. most issues with trannies are caused by low fluid level and mercedes trannies act weird if the level is extremely low.
There's a red lock tab which must be broken to unseal the fill tube, but there is no dipstick inside. You use a "dipstick tool" to check the level, which goes in the tube but isn't designed to be left in the transmission (as would be normal for the older boxes). This tool isn't very expensive. If I had a five-speed, I'd have one.