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Date registered: Nov 2007
Location: overlooking Silicon Valley
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I agree^, I had a loaner 07 E350 for a week while my ML350 was in shop, it was nice enough but boring.
I have 100K miles on the 08 C300, other than a couple of light bulbs, it's been nearly flawless while out of warranty. I don't see big differences in build quality. And based on CR reliability data and my own extensive experience with the current gen C-class, I'd be willing to bet the C-class is more reliable.
2013 Mercedes C250 Sport package PLUS steel gray metallic/black
2007 Lexus IS350 Sport package smoky granite mica/gray (+F-Sport, etc.)
2010 Honda Civic GX (CNG) white/tan