Date registered: Aug 2012
Vehicle: '94 S600 Sedan, '97 S600 Sedan, etc
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Several people here own E38's and W140's and most say the same thing:
E38's have a stiffer suspension so less comfortable than a W140, lacks double pane windows and other sound deadening materials so its not as quiet as a W140, W140 interior has a better build quality, hence more luxurious, the W140's chassis/suspension setup is also more comfortable or removed as you say.
Pro's of an E38: less expensive on maintenance (so the owners of both cars say), exterior looks better (their personal preference), its lighter and has a sportier steering so its more fun to drive.
E38: driver's car
W140: rider's car
As for my gas consumption, I dont pay attention to it at all. I didnt buy a 6.0 V12 to worry about fuel consumption and stuff like that. I fill it up, I drive, when the tank is empty, I fill it up again, repeat.
Previous: '79 240D, '84 190E, '88 300E, '93 300SE, '95 S500, '96 C280, '99 ML430
Current: '88 420SEL, '94 S600, '97 S600
I got the V12 fevah!