Well ..
Heres my take on the subject ( even though I'm without a W140 right now due to some issues on the seller of the vehicle having a lean on the title

so i got my $$ back and let him handle it and I'll keep looking )
The reason why the Bose system sounds so good is because all the speakers are enclosed and they are tuned. Also like stated above the amplifiers are designed very well and are slightly overpowering the speakers yet have built in limiters to prevent clipping and implementing an active crossover system to further reduce the frequencies that will damage or distort the sound after amplification.
But lets face it, the system was designed almost 15 years ago and the speaker technology this day if far ahead.
Here's the path i choose:
Headunit - KVT-819DVD
Nav - KNA-G510
Nav Traf - GXM30
Sirius - KCA-SR50
BT - KCA-BT100
TV Tuner - KTC-V300N
Amplifiers
4CH - KAC-X4R ( Front and Rear ) 4x 75RMS at 4ohms
1MB - KAC-X1R ( Parcel Shelf Subs ) 1x 600RMS at 4ohms or 1x 1200RMS at 2Ohms
Speakers
Front door*:
VR525-CSi
TR350-CXi
Rear Door:
TR-400CSi
Rear Parcel Shelf**
4x 8W3V3 ( if i can fit them )
OR
4x 6W3V3 ( if i cant )
*Tweeters from the 5.25 component set will be placed in the dash where the
factory cell integration speakers are for better imaging and will build a custom
matched 3 way passive cross over.
**Parcel Shelf subs will be 8ohm version run in parallel to drop them to 2ohms.
Possibly will build an enclosure or might use the trunk as an infinite baffle
NOTES:
With a little bit of math all volumes of the enclosures will be matched to new speakers to extract maximum efficiency out of them and the best sound possible by using closely matched caps and coils in the crossovers.
I have ordered most of the stuff already ( electronics are on route ) and will wait to have the car before i continue to order the speakers. Also i still have a little bit of work ahead of me on the on the custom crossovers for the front.
Mainly will be a SQ system with a multimedia branch.
As far as the mirror mounted speaker I'm doing research on an amplifier that would allow me to drive such a low impedance speaker to take advantage of it as a center channel when in theater mode.
EDIT:
There will be a 2 x 1 Farad Stiffening Capacitors to help keep stabilize the voltage and relive stress off the alternator as well. Factory battery will be replaced with 2 yellow top optimas which i will position one on each side of the trunk to improve weight distribution in the rear of the car.