Back at the Marbles, Raymond and Connie are making love by sucking each others toes, and we can see that their pubic hair is dyed to match the bright blue and red color of their hair. A phone call from Cookie interrupts them and she gives them the information she has collected about Divine's living arrangement and her birthday party. "You have no idea what I had to go through to get that information!" she tells them. The Marbles are thrilled that they know personal details about Divine, and they send her a surprise package in the mail--the address simply reads "Babs Johnson, A Trailer, Phoenix, Maryland".
At the trailer, Divine prepares the steak she shoplifted and feeds it to her family. A postman interrupts their dinner, and Divine confronts him angrily, furious that someone has dared to approach the trailer. When he runs off, she unwraps the package to discover human excrement inside. A birthday card announces that Divine is no longer The Filthiest Person Alive. Divine flies into a rage, swearing vengeance for the obscene gesture.
Connie and Raymond kidnap Linda (Linda Olgeirson), another young woman, after picking her up while hitch-hiking. They drug her and have Channing place her in the basement, where Susie begins to rant at him again. Channing, who is disgusted that part of his job is to have sex with unconscious women and get them pregnant, has devised a new method: he masturbates into his hand and uses a syringe to inject the semen into Linda's vagina.
Things progress. The Egg Man proposes marriage to Edie and she accepts, and he promises to take her to a large poultry factory for their honeymoon. The birthday party goes ahead as planned, with scores of guests indulging in all sorts of decadent behavior. Raymond and Connie, aware of the party, sneak up into the woods and watch from a distance as Divine snorts drugs with a friend, a woman performs a striptease with a snake, and in one of the movie's most memorable moments, a nude man throws his legs over his head an demonstrates his unusual ability to make his anus dilate rapidly over and over. Raymond and Connie are shocked at this display, and promptly phone the police to report Divine's party. The police arrive, but Divine and her group assassinate them with their bare hands, ripping their bodies apart and eating them raw as in "Night of the Living Dead".
Connie and Raymond, gloating over the fact that they've called the cops on Divine, return home to discover Channing dressed in Connie's clothes, imitating both Raymond and Connie. Furious, they lock him in his "room", which is really just a closet. They then set out for their final act of vengeance: to burn down Divine's trailer. Raymond finds time to stop at the local park to commit another act of indecent exposure, but he is horrified when his victim, a lovely young woman putting on makeup in the park, opens her dress to reveal that "she" has male genitals. She laughs with glee as Raymond runs off.
Divine and Crackers, having learned of the Marbles through gossip, invade the Marble residence, licking the furniture and rooms to "curse" the house. To further contaminate the dwelling, Divine and Crackers commit an act of incest, with Divine performing oral sex on him. They are interrupted by the sound of Channing, still locked inside the closet. They tie him up and intimidate him into telling them about Connie and Raymond. He also mentions the girls in the basement, and they take him downstairs to verify it. Sure enough, the imprisoned girls are there. Divine and Crackers disapprove of this variety of depravity committed by the Marbles, and they free the girls, allowing them to castrate Channing as an act of revenge.
Meanwhile, the Marbles invade Divine's trailer, now empty due to Edie's departure with her new husband. They pour gasoline all over and ignite it, delighting in their final act of aggression toward their enemy. After the Marbles run off, Divine returns with Crackers and Cotton to find the trailer ablaze. Beside herself with sorrow and rage, she sets out to seize the Marbles immediately.
When the Marbles return home, they discover their house has been contaminated. Their sofa and chair "reject" Connie and Raymond, spitting them onto the floor when they try and sit. The rest of the house reacts similarly as the Marbles walk through it in a panic. Discovering Channing's "room" empty, they wonder if he's set the girls free. In the basement pit, they find Channing's body, castrated and bled out. The girls are gone.
Connie and Raymond assume the girls have sent for the police and they try to flee, but Divine, Cotton, and Crackers are waiting for them in the living room. They abduct the Marbles, tying them up and taping their mouths shut, and drag them back to the site of the trailer for a "trial" and execution.
Divine summons the local tabloid press for exclusive coverage of the event. Representatives from three tabloids arrive and witness the mock trial for Connie and Raymond. Crackers and Cotton provide testimony and pronounce the verdict and punishment: guilty, with the death penalty to follow. After tarring and feathering the bound couple, Divine executes them with a handgun.
The reporters thank her for the scoop and depart to write their articles, while Divine has a discussion with Cotton and Crackers about their next move. They decide to change their appearances and move to Boise. Mr. J discusses their reputation in the last scene of the movie, which depicts the trio preparing to leave Baltimore for Boise. Divine spots a small dog moving its bowels, and in one movement, she kneels down and picks up the excrement and puts it in her mouth, chewing it briefly before spitting it out. The camera zooms in for a closeup of her face as she smiles and ends the movie.
Quis custodiet ipsos custodes?