Date registered: Nov 2005
Vehicle: 560/sel/sec/Jag XJS
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RE: Dog, Cardiomyopathy, Dilated ? anyone
What is cardiomyopathy?
Cardiomyopathy is a serious disease in which the heart muscle becomes inflamed and doesn't work as well as it should. There may be multiple causes including viral infections.
Cardiomyopathy can be classified as primary or secondary. Primary cardiomyopathy can't be attributed to a specific cause, such as high blood pressure, heart valve disease, artery diseases or congenital heart defects. Secondary cardiomyopathy is due to specific causes. It's often associated with diseases involving other organs as well as the heart.
There are three main types of cardiomyopathy -- dilated, hypertrophic and restrictive.
What is dilated (congestive) cardiomyopathy?
This is the most common form. In it, the heart cavity is enlarged and stretched (cardiac dilation). The heart is weak and doesn't pump normally, and most patients develop congestive heart failure. Abnormal heart rhythms called arrhythmias and disturbances in the heart's electrical conduction also may occur.
Blood flows more slowly through an enlarged heart, so blood clots easily form. A blood clot that forms in an artery or the heart is called a thrombus. A clot that breaks free, circulates in the bloodstream and blocks a small blood vessel is called an embolus.
* Clots that stick to the inner lining of the heart are called mural thrombi.
* If the clot breaks off the right ventricle (pumping chamber), it can be carried into the pulmonary circulation in the lung, forming pulmonary emboli.
* Blood clots that form in the heart's left side may be dislodged and carried into the body's circulation to form cerebral emboli in the brain, renal emboli in the kidney, peripheral emboli or even coronary artery emboli.
A condition known as Barth syndrome, a rare and relatively unknown genetically linked cardiac disease, can cause dilated cardiomyopathy. This syndrome affects male children, usually during their first year of life. It can also be diagnosed later. (For more information on Barth syndrome, visit the Barth Syndrome Foundation at http://www.barthsyndrome.org.)
In these young patients the heart condition is often associated with changes in the skeletal muscles, short stature and an increased likelihood of catching bacterial infections. They also have neutropenia, which is a decrease in the number of white blood cells known as neutrophils. There are clinical signs of the cardiomyopathy in the newborn child or within the first months of life. These children also have metabolic and mitochondrial abnormalities.
How is dilated (congestive) cardiomyopathy treated?
A person with cardiomyopathy may suffer an embolus before any other symptom of cardiomyopathy appears. That's why anti-clotting (anticoagulant) drug therapy may be needed. Arrhythmias may require antiarrhythmic drugs. More rarely, "heart block" may develop, requiring an artificial pacemaker. Therapy for dilated cardiomyopathy is sometimes disappointing, however. If the person is young and otherwise healthy, and if the disease gets worse and worse, a heart transplant may be considered.
When cardiomyopathy results in a significantly enlarged heart, the mitral and tricuspid valves may not be able to close properly, resulting in murmurs. Blood pressure may increase because of increased sympathetic nerve activity. These nerves can also cause arteries to narrow. This mimics hypertensive heart disease (high blood pressure). That's why some people have high blood pressure readings. Because the blood pressure determines the heart's workload and oxygen needs, one treatment approach is to use vasodilators (drugs that "relax" the arteries). They lower blood pressure and thus the left ventricle's workload.
What is hypertrophic cardiomyopathy?
In this condition, the muscle mass of the left ventricle enlarges or "hypertrophies."
In one form of the disease, the wall (septum) between the two ventricles (pumping chamber) becomes enlarged and obstructs the blood flow from the left ventricle. The syndrome is known as hypertrophic obstructive cardiomyopathy (H.O.C.M.) or asymmetric septal hypertrophy (A.S.H.). It's also called idiopathic hypertrophic subaortic stenosis (I.H.S.S.).
Besides obstructing blood flow, the thickened wall sometimes distorts one leaflet of the mitral valve, causing it to leak. In over half the cases, the disease is hereditary. Close blood relatives (parents, children or siblings) of such persons often have enlarged septums, although they may have no symptoms. This disease is most common in young adults.
In the other form of the disease, non-obstructive hypertrophic cardiomyopathy, the enlarged muscle doesn't obstruct blood flow.
The symptoms of hypertrophic cardiomyopathy include shortness of breath on exertion, dizziness, fainting and angina pectoris. (Angina is chest pain or discomfort caused by reduced blood supply to the heart muscle.) Some people have cardiac arrhythmias. These are abnormal heart rhythms that in some cases can lead to sudden death. The obstruction to blood flow from the left ventricle increases the ventricle's work, and a heart murmur may be heard.
How is hypertrophic cardiomyopathy treated?
The usual treatment involves taking a drug known as a beta blocker (such as propranolol) or a calcium channel blocker. If a person has an arrhythmia, an antiarrhythmic drug may also be used. Surgical treatment of the obstructive form is possible in some cases if the drug treatment fails.
Alcohol ablation is another nonsurgical treatment being developed for hypertrophic obstructive cardiomyopathy. It involves injecting alcohol down a small branch of one of the heart arteries to the extra heart muscle. This destroys the extra heart muscle without having to cut it out surgically.
People undergoing this procedure usually suffer chest pain during the alcohol injection. The alcohol can also disrupt normal heart rhythms and require the insertion of a pacemaker. Alcohol ablation is a relatively new procedure being performed at only a few specialized centers in the United States. It's too soon to know whether this treatment will result in long-term benefit. It's still considered experimental.